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For 51 years, Ghana’s oldest group medical practice has balanced the twin goals of supporting public health and managing a viable business. In 2020, its capabilities were put to the test by the Covid-19 pandemic. Nyaho Medical Center became an active participant in the country’s response. It provided rapid testing and treatment, helped organize public health measures such as contract tracing, and developed innovative practices in telemedicine. Nyaho also embraced the use of digital health records to reduce waiting time, coordinate patient services, and to support the effective management of hospital staff. In all these ways, Nyaho Medical Center demonstrated the resilience and responsiveness necessary for healthcare enterprises facing new global challenges such as the COVID-19 pandemic.